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In case inflammation of the joint in arthrosis deformans of the knee is conspicuous, and considering that the use of sodium hyaluronate may cause exacerbation of inflammatory symptoms of the affected part, it is desired that treatment be given after such inflammatory symptoms have been eliminated.
Occasionally, local pain occurs after the use of sodium hyaluronate, therefore, necessary measures should be taken eg, instruction of how to rest the affected part after application of sodium hyaluronate.
If the injection should leak outside the articular cavity, it may cause pain, therefore, it should be administered accurately into the cavity of the joint.
Administer with care in patients with history of hypersensitivity to some other drug, with liver impairment or a history of such impairment.
The safety and effectiveness of the use of joints other than the knee have not been established.
Use with caution when injecting into patients who are allergic to avian proteins, feathers and egg products.
Remove joint effusion, if present, before injecting sodium hyaluronate.
Use in pregnancy & lactation: In animal experiment (rabbit), teratogenicity is not observed, however, safety of sodium hyaluronate in pregnant women has not yet been established, therefore, it should be administered carefully in women who are or possibly are pregnant.
In animal experiment (rat), it is recognized that sodium hyaluronate can pass into breast milk.
The safety and effectiveness of sodium hyaluronate have not yet been established in pregnant and lactating women.
Use in children: As safety of sodium hyaluronate in children has not yet been established, administration should be carefully made only if such treatment is unavoidable.
Use in the elderly: Administer with caution in elderly patients because their physiological function is generally declining.
